Obstructive sleep apnea in Prader-Willi syndrome: risks and advantages of adenotonsillectomy

Submitted: 4 March 2015
Accepted: 14 August 2015
Published: 24 November 2015
Abstract Views: 2451
PDF: 1626
HTML: 686
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Obstructive sleep apnea is a well-known clinical manifestation of Prader-Willi syndrome. The aim of our study is to evaluate the efficacy of adenotonsillectomy for the treatment of the disorder as well as the improvement of their post-operative quality of life. Five patients with moderate to severe obstructive sleep apneas and adenotonsillar hypertrophy of grade III-IV underwent adenotonsillectomy. Pre- and postoperative apneas and Quality of Life were assessed respectively with a polysomnography with multi-sleep latency test and with the pediatric Quality of Life questionnaire, performed before and 6 months after surgery. A decrease of apnea/hypopnea index values has been detected between pre- and post-surgery (t=2.64, P=0.005), as well as oxygen desaturation index values (t=5.51, P=0.005), multi-sleep latency test (t=4.54, P=0.01), and of the values of pediatric Quality of Life questionnaire. No correlation has been detected between body mass index and apnea/hypopnea index, oxygen desaturation index and multi-sleep latency test values pre- and post-adenotonsillectomy. A correlation has been found between multi-sleep latency test and oxygen desaturation index values post-surgery (P=0.04). No post-operative complications were observed. Our data underline the efficacy of surgery in Prader-Willi patients with adenotonsillar hypertrophy in order to improve their quality of life.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

How to Cite

Giordano, L., Toma, S., Palonta, F., Teggi, R., Zucconi, M., Di Candia, S., & Bussi, M. (2015). Obstructive sleep apnea in Prader-Willi syndrome: risks and advantages of adenotonsillectomy. La Pediatria Medica E Chirurgica, 37(2). https://doi.org/10.4081/pmc.2015.107

Similar Articles

1 2 3 4 5 6 > >> 

You may also start an advanced similarity search for this article.