Frontal bone fibrous dysplasia in a 6-months-old boy: A distinctive entity

  • Kleanthis Anastasiadis | kaanastasiadis1@gmail.com 2nd Department of Pediatric Surgery, Aristotle University of Thessaloniki, General Hospital “Papageorgiou”, Thessaloniki, Greece. https://orcid.org/0000-0002-2713-7504
  • Vassilis Lambropoulos 2nd Department of Pediatric Surgery, Aristotle University of Thessaloniki, General Hospital “Papageorgiou”, Thessaloniki, Greece. https://orcid.org/0000-0002-7034-7259
  • Kalliopi Tsoleka Neurosurgeon,Chief of the Neurosurgery Department, General Hospital “Papageorgiou”, Thessaloniki, Greece.
  • Chrysostomos Kepertis 2nd Department of Pediatric Surgery, Aristotle University of Thessaloniki, General Hospital “Papageorgiou”, Thessaloniki, Greece. https://orcid.org/0000-0001-6726-085X
  • Vassilis Mouravas 2nd Department of Pediatric Surgery, Aristotle University of Thessaloniki, General Hospital “Papageorgiou”, Thessaloniki, Greece. https://orcid.org/0000-0002-7555-1187
  • Ioannis Spyridakis 2nd Department of Pediatric Surgery, Aristotle University of Thessaloniki, General Hospital “Papageorgiou”, Thessaloniki, Greece.

Abstract

Fibrous Dysplasia (FD) is a non-malignant condition caused by post-zygotic, activating mutations of the GNAS gene that results in inhibition of the differentiation and proliferation of bone-forming stromal cells and leads to the replacement of normal bone and marrow by fibrous tissue and woven bone. The clinical behavior and progression of FD is variable. The management of this condition is difficult and in every case is strictly individualized. We report a case of frontal fibrous dysplasia in a 6month’s old boy who underwent a successfully resection of the lesion with an excellent cosmetic effect.

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References

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Published
2021-03-19
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Case Reports
Keywords:
Fibrous dysplasia, GNAS mutation, 6-months-old boy
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How to Cite
Anastasiadis, K., Lambropoulos, V., Tsoleka, K., Kepertis, C., Mouravas, V., & Spyridakis, I. (2021). Frontal bone fibrous dysplasia in a 6-months-old boy: A distinctive entity. La Pediatria Medica E Chirurgica, 43(1). https://doi.org/10.4081/pmc.2021.225