Precocious puberty in a patient with Oculo-Auriculo-Verebral spectrum (OAVS)

Submitted: 13 November 2014
Accepted: 13 November 2014
Published: 30 June 2014
Abstract Views: 1196
PDF: 1185
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

The authors report on the first case of OAVS (Oculo-Auriculo- Vertebral-Spectrum), with hemifacial microsomy, hydrocephalus, pubertas precox, thelarche at 4 years of age, vaginal bleeding at 5 years, and left ovary of adult type on echography (right ovary initially not visualized). FISH and CGH-ARRAYS methods were negative. By GnRH therapy the delay of onset puberty was obtained. The authors ascribe facial and ovary asymmetry to a derangement of blastogenesis, during which axial right-left structures begin the develop with consequent migration or interation with surrounding tissues of neural crest cells and alteration of diencephalic pituitary systems.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

How to Cite

Berio, A., Garlaschi, G., & Piazzi, A. (2014). Precocious puberty in a patient with Oculo-Auriculo-Verebral spectrum (OAVS). La Pediatria Medica E Chirurgica, 36(3). https://doi.org/10.4081/pmc.2014.11

Similar Articles

<< < 1 2 3 4 > >> 

You may also start an advanced similarity search for this article.