https://doi.org/10.4081/pmc.2023.308

Ureteropelvic junction obstruction in children by polar vessels: histological examination result

Vol. 45 No. 1 (2023)
Submitted: 17 January 2023
Accepted: 15 May 2023
Published: 30 May 2023
ureteropelvic junction obstruction, polar vessel, histological differences, immunohisthochemical investigations
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Authors

Eugenia Piro
eugenia.piro@asst-ovestmi.it
Paediatric Surgery, ASST Ovest Milanese, Legnano Hospital, Italy.
Fabiola Colombini
Paediatric Surgery, ASST Ovest Milanese, Legnano Hospital, Italy.
Marta Brugnoni
Paediatric Surgery, ASST Ovest Milanese, Legnano Hospital, Italy.
Daniele Perilli
Paediatric Surgery, ASST Ovest Milanese, Legnano Hospital, Italy.
Laura Caterina Abati
Paediatric Surgery, ASST Ovest Milanese, Legnano Hospital, Italy.
Veronica Zocca
Paediatric Surgery, ASST Ovest Milanese, Legnano Hospital, Italy.
Lucia Vallieri
https://orcid.org/0000-0001-6410-419X
athological Anatomy, ASST Ovest Milanese, Legnano Hospital, Italy.
Antonio D'Alessio
Paediatric Surgery, ASST Ovest Milanese, Legnano Hospital, Italy.

In children, ureteropelvic junction obstruction (UPJO) is mostly caused by intrinsic factors (IUPJO) such as abnormal amounts of muscle and collagen deposition; extrinsic UPJO are rare and often due to crossing vessels (CVs). What is not clear is whether there is also intrinsic UPJ pathology in patients with CV. The aim of our study was to compare the histology of the two types of obstruction and to determine whether these histologic features are distinguishable enough to enable to identify the cause of obstruction based on histologic appearance alone. We retrospectively reviewed pathology reports of 38 children with UPJO that underwent surgery in our hospital from 2008 to 2022. The intrinsic and extrinsic groups consisted of 18 and 20 patients, respectively. After ematoxylin-eosin and Gomori's trichrome staining the specimens were scored for fibrosis and muscular hypertrophy in histhopatology, and CD117 antibody were used to detect interstitial Cajal-like cells. In our study, histological analyses revealed no differences between the CV and IUPJO specimens in terms of presence and degree of fibrosis and muscular hypertrophy; likewise, for presence of interstitial Cajal-like cells.

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How to Cite

Piro, E., Colombini, F., Brugnoni, M., Perilli, D., Abati, L. C., Zocca, V., … D’Alessio, A. (2023). Ureteropelvic junction obstruction in children by polar vessels: histological examination result. La Pediatria Medica E Chirurgica, 45(1). https://doi.org/10.4081/pmc.2023.308
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